Electric Literature of 5345-47-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5345-47-1, name is 2-Aminonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
Containing 13.8 g of 2-amino acid (0.1 mmol) of potassium carbonate and 27.6 g (0.2 mole, 2.0 eq.) Of dimethyl sulfoxide was heated to reflux, then the solution was cooled to ambient temperature, was added 14.2 g of iodine methane (0.1 mole, 1.0 eq) to the mixture, and the solution was stirred for 18 hours, the mixture was filtered and concentrated to give a residual material containing 0.1% aqueous ammonia (5/95 ethanol / dichloromethane) was eluted as after filtration of the liquid silicone pad and the resulting solution was concentrated, the residue was suspended in ether, filtered and dried to give 2-amino-nicotinic acid methyl ester (10.8 g, 71% yield). Analysis of results:
According to the analysis of related databases, 5345-47-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOGEN MA INC.; SUNESIS PHARMACEUTICALS, INC.; ARNDT, JOSEPH; CHAN, TIMOTHY; GUCKIAN, KEVIN; KUMARAVEL, GNANASAMBANDAM; LEE, WEN-CHERNG; LIN, EDWARD YIN-SHIANG; SCOTT, DANIEL; SUN, LIHONG; THOMAS, JERMAINE; VAN VLOTEN, KURT; WANG, DEPING; ZHANG, LEI; ERLANSON, DANIEL; (469 pag.)TWI525093; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem