With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.92992-85-3, name is 2-Bromo-3,5-dimethylpyridine, molecular formula is C7H8BrN, molecular weight is 186.0491, as common compound, the synthetic route is as follows.HPLC of Formula: C7H8BrN
[0085 -Step e: Preparation of 2′,5′-dichloro-3,5-dimethyl-2,4′-bipyridine [0086] To a solution of 2,5-dichloropyridin-4-ylboromc acid (7.56 g, 40 mmol), 2-bromo- 3,5- dimethylpyridine (5.62 g, 30 mol) in dioxane (60 mL) and H?0 (12 mL) were added Pd(dppf)CI2 (1.35 g, 1.7 mmol) and K :'( ) · 31 >( > (16.2 g, 60 mmol), the mixture was stirred at reflux under N2 atmosphere overnight. TLC showed the reaction was complete. After cooling to room temperature, the mixture was filtered. Water (50 mL) was then added to the filtrate. The mixture was extracted with dichloromethane (150 mL x 3). The combined organic layers were washed with brine (300 mL), dried over Na2S04, filtered and concentrated. The residue was purified by silica gel column chromatography (petroleum ether/EtOAc = 20:1 to 10:1) to give title compound (3.1 g, 41%) as a white solid. NMR (400MHz, CDCI3): delta 8.46 (s, 1 H), 8.37 (s, 1 H), 7.47 (s, 1 H), 7.33 (s, 1 H), 2.39 (s, 3H), 2.16 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,92992-85-3, 2-Bromo-3,5-dimethylpyridine, and friends who are interested can also refer to it.
Reference:
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem