Reference of 50488-42-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 50488-42-1, name is 2-Bromo-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.
III. methyl 5-trifluoromethyl-pyridine-2-carboxylate A mixture of 2-bromo-5-trifluoromethyl-pyridine (10 g, 44.25 mmol), TEA (17.9 g, 177 mmol) and Pd(dppf)Cl2 (3.24 g, 4.42 mmol) was stirred at 80C under an average pressure of 1.5 MPa with CO gas. The reaction mixture was filtered and the filtrate was concentrated. The residue was extracted between EA (100 mL) and H20 (100 mL). The EA layer was washed with saturated aqueous NaHC03 (2 X 100 mL), brine (1 X 100 mL), dried, concentrated and purified by column chromatography on silica gel to give the title compound as a white solid (6 g, 66% yield): 1H NMR (400 MHz, CDC13) delta ppm 8.97-8.98 (m, 1H), 8.23-8.25 (m, 1H), 8.07-8.09 (m, 1H), 4.03 (s, 3H); ES-LCMS m/z 206 ( +H)+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50488-42-1, 2-Bromo-5-(trifluoromethyl)pyridine.
Reference:
Patent; GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, IV, Siegfried Benjamin; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing; LIN, Xiaojuan; XU, Shanli; LV, Maoyun; YAO, Chen; LI, Lei; HUANG, Xing; GAO, Min; WO2013/166621; (2013); A1;,
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