The origin of a common compound about 2-Chloro-5-nitropyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4548-45-2, 2-Chloro-5-nitropyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4548-45-2, name is 2-Chloro-5-nitropyridine, molecular formula is C5H3ClN2O2, molecular weight is 158.54, as common compound, the synthetic route is as follows.category: pyridine-derivatives

To a solution of 2-chloro-5-nitropyridine (LXV) (2.0 g, 12.6 mmol) in EtOH (20 mL) was added tert-butyl piperazine-l-carboxylate (XCVI) (7.05 g, 37.9 mmol). The reaction was headed at 70C for 16 h. The reaction was concentrated under vacuum and then dissolved in EtOAc. The EtOAc was washed with 1 M NaOH, brine and then dried over MgS04 to give tert-butyl 4-(5-nitropyridin-2-yl)piperazine-l- carboxylate (XCVII) as a yellow solid (4.94 g). ESIMS found for C14H20N4O4 mlz 309.0 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4548-45-2, 2-Chloro-5-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; SAMUMED, LLC; HOOD, John; KC, Sunil Kumar; WO2013/40215; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem