Adding a certain compound to certain chemical reactions, such as: 69045-78-9, 2-Chloro-5-(trichloromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 69045-78-9, blongs to pyridine-derivatives compound. Recommanded Product: 69045-78-9
Example 4 In a 3000 cc autoclave equipped with a magnetic stirrer, a 40% aqueous solution of methylamine (814 g), ethanol (312 g) and Raney nickel (35 g) were charged. Hydrogen gas was introduced into the autoclave to a pressure of 3 Kg/cm2. While keeping a temperature at 30 C. or lower and supplying the hydrogen gas, a 58.8% solution of 2-chloro-5-trichloromethylpyridine in toluene (589 g) was added over 40 minutes. After the addition of the solution of 2-chloro-5-trichloromethylpyridine, the internal temperature was gradually raised to 40 C. At the same temperature, the hydrogen gas was supplied till the absorption of hydrogen ceased. After completion of reaction, the autoclave was cooled to room temperature, and the catalyst was filtrated off from the reaction mixture. The filtrate was analyzed by high pressure liquid chromatography to find that a yield of 2-chloro-5-methylaminomethylpyridine was 76%.
The synthetic route of 69045-78-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Koei Chemical Co., Ltd.; US5424437; (1995); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem