Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1945-84-2, name is 2-Ethynylpyridine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1945-84-2
General procedure: To a stirred solution of the glycosyl azide 2 (1 mmol for alkynes 1a,b,c; 2 mmol for 1d) in t-BuOH-H2O (4:1, 100 mL) was added the alkynyl compound 1 (1 mmol), CuSO4·H2O (50 mg, 0.2 mmol for 1a,b,c; 100 mg, 0.4 mmol for 1d), and sodium ascorbate (80 mg, 0.4mmol for 1a,b,c; 160 mg, 0.8 mmol for 1d). The resulting solution was stirred at 40 C until TLC (eluent: see individual examples) showed complete consumption of the starting material (12-48 h). The reaction mixture was diluted with H2O (100 mL) and extracted with CH2Cl2 (3 × 50 mL). The combined organic layers were washed with 1M aq EDTA solution (50 mL) and H2O (50 mL), dried (Na2SO4), filtered,and concentrated. Flash chromatography or crystallization of thecrude product gave compounds 3-6.
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Reference:
Article; Kraft, Jochen; Schmollinger, Daniel; Maudrich, Jakob; Ziegler, Thomas; Synthesis; vol. 47; 2; (2015); p. 199 – 208;,
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