Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131747-55-2, name is 2-Fluoro-3-(hydroxymethyl)pyridine. A new synthetic method of this compound is introduced below., Product Details of 131747-55-2
The above example 2-fluoropyridin-3-yl-methanol was dissolved in 85 mL of dichloromethane,Ice bath 10min,21.7 mL (306.04 mmol) of thionyl chloride was slowly added dropwise.The reaction solution changed from yellow to brown, and the reaction was continued for 2 hours.TLC monitoring, the reaction is complete, continue the ice bath for a while, slowly add 100mL of water, N2 blow, alkali absorption gas, dichloromethane (100mL*3) extraction, 100mL saturated brine, dry anhydrous MgSO4, vacuum distillation Solvent, 7.14g of brown liquid, ready for use
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Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Li Song; Zheng Zhibing; Lin Feng; Gong Zehui; Lu Xinqiang; Zhou Xinbo; Zhong Wu; Xiao Junhai; Xie Yunde; Li Xingzhou; Wang Xiaokui; (16 pag.)CN107964018; (2018); A;,
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