Adding a certain compound to certain chemical reactions, such as: 58530-50-0, 2-(Pyridin-2-yloxy)acetic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 58530-50-0, blongs to pyridine-derivatives compound. Quality Control of 2-(Pyridin-2-yloxy)acetic acid
General procedure: To the mixture of compounds (IVa-c)(2 mmol) in dry acetonitrile (15 mL), triethylamine(3 mmol) followed by substituted piperazines(2 mmol) was added. The mixture was stirred for30 min and TBTU (2mmol) was then added and stirring was continued at room temperature under an inert atmosphere for 10-24 h; the completion of thereaction was monitored by TLC using chloroform-methanol (9 : 1) as eluent. The solvent was evaporatedat reduced pressure, quenched by the addition of coldwater (20 mL), and the obtained solids (Va), (Vb), (Vc),(Vd), (Ve), (Vf), (Vi), and (Vk) were filtered, dried, andrecrystallized from ethanol. In contrast, compounds(Vg), (Vh), (Vj), and (Vl) were obtained by extractingwith ethyl acetate. The extract was washed successivelywith a solution of 10% HCl (20 mL), 10% NaHCO3(20 mL), and water (20 mL). The organic layer wasdried over anhydrous sodium sulfate and evaporated,the crude product was purified by column chromatography (eluent: hexane-dichloromethane-acetone,5 : 3 : 2) to achieve pure piperazine derivatives. Thephysical and analytical data of the synthesized titlecompounds (Va-l) are given below.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58530-50-0, its application will become more common.
Reference:
Article; Al-Ghorbani; Rekha; Lakshmi Ranganatha; Prashanth; Veerabasappagowda; Khanum; Russian Journal of Bioorganic Chemistry; vol. 41; 5; (2015); p. 554 – 561; Bioorg. Khim.; vol. 41; 5; (2015); p. 554 – 561,8;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem