Reference of 20173-24-4 ,Some common heterocyclic compound, 20173-24-4, molecular formula is C7H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
3.1 g (?3.5 mmol) PS-carbodiimide was added to a solution of 244 mg (2.0 mmol) 2-(pyridine-3-yl)ethylamine and 542 mg (3.0 mmol) 3-(3-chlorophenyl)-propiolic acid in DCM (50 ml) and the reaction solution was shaken for 16 h at RT. The resin was subsequently filtered off and rinsed with DCM and MeOH. The filtrate was concentrated in a vacuum and CC(CHCl3/MeOH 40:1) was performed with the residue, whereby 447 mg (1.6 mmol, 80%) 3-(3-chlorophenyl)-N-(2-(pyridine-3-yl)ethyl)propiolamide was obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 20173-24-4, 2-(Pyridin-3-yl)ethanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GRUNENTHAL GMBH; US2009/182020; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem