Adding a certain compound to certain chemical reactions, such as: 889865-45-6, 2,3-Dichloro-4-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H2Cl2IN, blongs to pyridine-derivatives compound. Formula: C5H2Cl2IN
A solution of 3-amino-5-chloropyrazine-2-thiol (TFA salt: 0.50 g, 1.814 mmol) in dioxane (90 mL) was degassed with nitrogen for 10 min. Then, 2,3-dichloro-4-iodopyridine (0.0.99 g, 3.63 mmol), Xantphos (0.105 g, 0.181 mmol), Pd2(dba)3 (0.083 g, 0.091 mmol), and DIPEA (0.95 mL, 5.44 mmol) were added. The resulting mixture was stirred at 105 C for 10 h, filtered through Celite and concentrated. The crude was purified by silica chromatography (0- 10% gradient of EtOAc DCM). NMR (400 MHz, DMSO-t/6) delta ppm 8.13 (d, J=5.3 Hz, 1 H), 7.95 (s, 1 H), 7.30 (br. s, 2 H), 6.83 (d, J=5.3 Hz, 1 H). MS m/z 306.9 (M+H)+
The synthetic route of 889865-45-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; CHEN, Christine Hiu-tung; CHEN, Zhuoliang; DORE, Michael; FORTANET, Jorge Garcia; KARKI, Rajesh; KATO, Mitsunori; LAMARCHE, Matthew J.; PEREZ, Lawrence Blas; SMITH, Troy Douglas; WILLIAMS, Sarah; GIRALDES, John William; TOURE, Bakary-barry; SENDZIK, Martin; WO2015/107495; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem