Synthetic Route of 180995-12-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.180995-12-4, name is 2,4-Dichloronicotinonitrile, molecular formula is C6H2Cl2N2, molecular weight is 173, as common compound, the synthetic route is as follows.
To a mixture of 5-amino-1-methyl-1 H-benzo[d]imidazol-2(3/-/)-one (750 mg, 4.6 mmol) and 2,4-dichloropyridine-3-carbonitrile (760 mg, 4.4 mmol) under argon was added DMA (10 mL) followed by DIPEA (0.90 mL, 5.19 mmol) . The reaction mixture was heated at 120C under microwave irradiation for 45 min then allowed to cool to rt and added dropwise to a stirring mixture of methanol:water (1 : 1 ; 120 mL). The resulting precipitate was filtered, washed with water (2 x 25 mL) and diethyl ether (2 x 30 mL) affording 2-chloro-4-[(1-methyl- 2-oxo-3/-/-benzimidazol-5-yl)amino]pyridine-3-carbonitrile (1297 mg, 99%, 4.3 mmol) as a beige solid. 1 H NMR (500 MHz, DMSO-cfe) delta 10.95 (br s, 1 H), 9.39 (br s, 1 H), 7.99 (d, J = 6.2 Hz, 1 H), 7.13 (d, J = 8.3 Hz, 1 H), 6.95 (dd, J = 8.3, 1.9 Hz, 1 H), 6.90 (d, J = 1.9 Hz, 1 H), 6.65 (d, J = 6.2 Hz, 1 H).
The chemical industry reduces the impact on the environment during synthesis 180995-12-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; BELLENIE, Benjamin Richard; CARTER, Michael Keith; CHEUNG, Kwai Ming Jack; DAVIS, Owen Alexander; HOELDER, Swen; LLOYD, Matthew Garth; VARELA RODRIGUEZ, Ana; (381 pag.)WO2018/215801; (2018); A1;,
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