Application of 942473-59-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 942473-59-8 as follows.
2,5-Dibromopyridine-4-carboxylic acid (25.0 g) is dissolved in MeOH (400 ml.) and cone, sulfuric acid (5 ml.) is added dropwise at ambient temperature. The reaction is heated to reflux and stirred for 16 h. After cooling to ambient temperature the solution is concentrated under reduced pressure and partitioned between EtOAc and aq. sat. NaHCO-3. The organic phase is washed with aq. sat. NaHCO-3, dried over Na2S04, solid parts are removed by filtration and concentrated under reduced pressure. Column chromatography of the resulting crude product (ISCO-CombiFlash Rf, cyclohexane/EtOAc) yields the title compound (23.8 g, yield 91 %) as a colorless oil. (2134) H NMR (400 MHz, DMSO-c 6): delta = 8.77 (s, 1 H), 8.01 (s, 1 H), 3.91 (s, 3H) ppm; MS (ESI) m/z 295.9 [M + H+].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,942473-59-8, its application will become more common.
Reference:
Patent; BASF SE; VOGT, Florian; WITSCHEL, Matthias; SEISER, Tobias; LOPEZ CARRILLO, Veronica; SEITZ, Thomas; KRAEMER, Gerd; KREUZ, Klaus; NEWTON, Trevor William; REINHARD, Klaus; SCHACHTSCHABEL, Doreen; TRESCH, Stefan; (109 pag.)WO2018/19758; (2018); A1;,
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