Reference of 60010-03-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60010-03-9, name is 2,6-Dichloro-4-methyl-3-nitropyridine, molecular formula is C6H4Cl2N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2,6-Dichloro-4-methyl-3-nitropyridine (Step 31.1;1.17 g, 5.68 mmol) was added at rtto a 2M solution of methylamine in THF and alowed to stir for 30 mm. The reaction mixture was then diluted with EtOAc/water, extracted twice with EtOAc and the combined organic extracts were washed with brine, dried (Na2504) and concentrated. The crude product was purified by flash chromatography (ISCO combi flash; EtOAc/hexanes: 1:4, 5i02) to afford the title compound as a yellow solid. tR: 1.08 mm (LC-MS 2); ESl-MS: 202.0 [M+H]1H NMR (400 MHz, DMSO-d6) 0 ppm 2.39 (5, 3 H) 2.90 (d, J=4.65 Hz, 3 H) 6.73 (5, 1 H) 7.95 (d, J=3.91 Hz, 1 H).
According to the analysis of related databases, 60010-03-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; BLANK, Jutta; BOLD, Guido; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; WO2014/191894; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem