The origin of a common compound about 2942-59-8

Statistics shows that 2942-59-8 is playing an increasingly important role. we look forward to future research findings about 2-Chloronicotinic acid.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2942-59-8, name is 2-Chloronicotinic acid, molecular formula is C6H4ClNO2, molecular weight is 157.55, as common compound, the synthetic route is as follows.2942-59-8

To a solution of 2-chloronicotinic acid (B-1) (7.88 g, 50.0 mmol) in THF (100 mL) was added methyl magnesium bromide (42 mL, 3M ethyl ether solution) dropwise under 0 ¡ãC. Upon completion of the addition, the reaction mixture was stirred at 0 ¡ãC for 0.5 h and then at room temperature overnight. The reaction mixture was added into ice/water (150 mL), and extracted with ethyl acetate. The combined organic layers were dried over Na2S04 and concentrated to afford the title compound 1 -(2-chloropyridin-3-yl)ethanone (B-2). MS (m/z): 156 (M+1 )+.

Statistics shows that 2942-59-8 is playing an increasingly important role. we look forward to future research findings about 2-Chloronicotinic acid.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu; WO2011/79804; (2011); A1;,
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