Adding a certain compound to certain chemical reactions, such as: 26163-03-1, 3-Bromo-5-chloropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H4BrClN2, blongs to pyridine-derivatives compound. HPLC of Formula: C5H4BrClN2
Under nitrogen protection,Acetonitrile (100 mL) was added sequentially to a 500 mL three-necked flask,Elemental iodine (48.9 g, 192.8 mmol)Cuprous iodide (23.9 g, 125.3 mmol) andTert-butyl nitrite (14.9 g, 144.6 mmol)2-Amino-3-bromo-5-chloropyridine (20.0 g, 96.4 mmol) was slowly added under ice-cooling to react at 60 C for 2 h.After completion of the reaction, water (45 mL) was added,The filter cake was extracted with ethyl acetate (45 mL x 1) and the filtrate was extracted with ethyl acetate (200 mL x 2)The phases were washed with saturated aqueous sodium thiosulfate solution (110 mL x 2), dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure.A small amount of methanol beating, filter, filter cake after drying 2 – iodo-3-bromo-5-chloropyridine white solid 21.9g, the yield of 71.2%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,26163-03-1, 3-Bromo-5-chloropyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; Guizhou University; Zhao, Chunshen; Chai, Huifang; Zhou, Zhixu; Le, Yi; Liu, Li; Teng, Minggang; Huang, Zhuyan; (5 pag.)CN106467488; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem