Related Products of 799293-73-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 799293-73-5, name is 3-Bromofuro[3,2-c]pyridin-4-amine, molecular formula is C7H5BrN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1, 1-dimethylethyl 5-(4-aminofurof3,2-clDyridin-3-yl)-4-fluoro-2,3-dihvdro-1H-indole-1- carboxylate3-Bromofuro[3,2-c]pyridin-4-amine (310 mg, 1 .455 mmol), 1 , 1-dimethylethyl 4-fluoro-5- (4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-2,3-dihydro-1 H-indole-1-carboxylate (577 mg, 1 .589 mmol), PdCI2(dppf)-CH2CI2 adduct (65 mg, 0.080 mmol), 1 ,4-Dioxane (15 mL), and saturated aqueous sodium bicarbonate (4.5 mL, 4.50 mmol) were added to a 200 mL flask equipped with a reflux condenser. The flask was evacuated and filled with nitrogen 4 times, and then the mixture was stirred at 100 C under Nitrogen for 15 hours. LCMS showed complete and clean conversion, so it was cooled and filtered through celite, rinsing with EtOAc (50 mL). The filtrate was washed with half-saturated aqueous NaHC03 (50 mL), and the aqueous phase was back-extracted with ethyl acetate (2 chi 50 mL). The combined organic phases were washed with brine (1 chi 100 mL), dried (Na2S04), filtered, and concentrated in vacuo. The residue was purified by flash chromatography (Analogix, 60 g Si02, 10%-75% EtOAc in hexanes gradient over 60 minutes) to give 1 ,1 -dimethylethyl 5-(4-aminofuro[3,2-c]pyridin-3-yl)-4-fluoro-2,3-dihydro- 1 H-indole-1 -carboxylate (205 mg, 0.555 mmol, 38.1 % yield) as an off-white solid. LC/MS (ES) m/z = 370 [M+H]+
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 799293-73-5, 3-Bromofuro[3,2-c]pyridin-4-amine.
Reference:
Patent; GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; GRANT, Seth, Wilson; HEERDING, Dirk, A.; MEDINA, Jesus, Raul; ROMERIL, Stuart, Paul; TANG, Jun; WO2011/119663; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem