Reference of 799293-73-5, Adding some certain compound to certain chemical reactions, such as: 799293-73-5, name is 3-Bromofuro[3,2-c]pyridin-4-amine,molecular formula is C7H5BrN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 799293-73-5.
-(4-aminofuror3,2-clpyridin-3-yl)-2,3-dihvdro-1 H-indole-1-carboxylateA mixture of 3-bromofuro[3,2-c]pyridin-4-amine (3.002 g, 14.09 mmol), 1 ,1 -dimethylethyl 5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-2,3-dihydro-1 H-indole-1-carboxylate (5.346 g, 15.48 mmol), and PdCI2(dppf)-CH2CI2 adduct (0.573 g, 0.702 mmol) in 1 ,4-Dioxane (120 ml.) and saturated aqueous sodium bicarbonate (43 ml_, 43.0 mmol) was degassed with Nitrogen for 20 minutes. The mixture was then stirred at reflux under Nitrogen for 16 hours. It was then cooled, poured into half-saturated aqueous NaHC03 (250 ml_), and extracted with ethyl acetate (2 250 ml_). The extracts were washed with brine (1 * 250 ml_), dried (Na2S04), filtered, and concentrated in vacuo. The residue was purified by flash chromatography (Analogix, 400 g Si02, 20%-100% EtOAc in hexanes gradient over 60 minutes, then 100% EtOAc for 15 more minutes) to give 1 , 1 -dimethylethyl 5-(4- aminofuro[3,2-c]pyridin-3-yl)-2,3-dihydro-1 H-indole-1 -carboxylate (3.93 g) as an off-white solid. LC/MS (ES) m/z = 352 [M+H]+.
According to the analysis of related databases, 799293-73-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; GRANT, Seth, Wilson; HEERDING, Dirk, A.; MEDINA, Jesus, Raul; ROMERIL, Stuart, Paul; TANG, Jun; WO2011/119663; (2011); A1;,
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