Related Products of 67346-74-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67346-74-1, name is 3-Ethynylpyridin-2-amine, molecular formula is C7H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Manufacturing Example 1-4-1: Di-tert-butyl (3-ethynylpyridin-2-yl)imide dicarbonate; 3-Ethynyl-pyridin-2-ylamine (6.34 g) described in Manufacturing Example 1-2-3 of International Publication WO 07/052,615, di-tert-butyl dicarbonate (58.5 g), triethylamine (27.1 g), 4-dimethylaminopyridine (655 mg), and tetrahydrofuran (254 mL) were stirred for 18 hours at room temperature. Silica gel was added to the reaction solution, and the solvent was concentrated under a reduced pressure. The silica gel thus obtained was purified by silica gel chromatography (heptane:ethyl acetate=3:1) to obtain the title compound (15 g) as a white solid.1H-NMR spectrum (DMSO-d6) delta (ppm): 1.32 (18H, s), 4.59 (1H, s), 7.39-7.44 (1H, m), 7.99-8.03 (1H, m), 8.46-8.48 (1H, m).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 67346-74-1, 3-Ethynylpyridin-2-amine.
Reference:
Patent; Eisai R&D Management Co. Ltd.; US2009/233883; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem