In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 932-35-4, name is 3-Hydroxypicolinonitrile, the common compound, a new synthetic route is introduced below. Quality Control of 3-Hydroxypicolinonitrile
Reference Example 23: N-(5-chloropyridin-2-yl)-2-[(2-cyanopyridin-3-yl)oxy]acetamide; [] 2-Cyano-3-hydroxypyridine (35.0 g) obtained according to the method described in a literature (Synthesis 1983, 316) is dissolved in acetone (800 ml), and thereto are added 2-chloro-N-(5-chloropyridin-2-yl)acetamide (62.6 g) obtained in Reference Example 21, potassium carbonate (60.0 g) and sodium iodide (45.8 g). The mixture is then heated under reflux for 2 hours. After allowing to cool, water and ethyl acetate are poured to the reaction mixture, and the insoluble materials are removed by filtration. The organic layer is then separated. The aqueous layer is extracted with ethyl acetate and the organic layers are combined, washed with saturated brine and dried over sodium sulfate. The solvent is removed by evaporation under reduced pressure and the resulting residue is suspended in diethyl ether. The precipitates are collected by filtration to give the title compound (80.3 g). APCI-MS M/Z:289/291[M+H]+.
The synthetic route of 932-35-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; EP1582521; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem