Reference of 20265-37-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20265-37-6, name is 3-Methoxy-2-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.
The compound forms a neutral fumarate, which after recrystallisation from a mixture of isopropanol and acetone melts, as the hydrate, at 124-126. The starting material can be prepared as follows: 26.5 g of sodium hydride are added in the course of one hour to a mixture of 161 g of 3-methoxy-2-nitropyridine and 144 g of 2,2-dimethyl-5-hydroxymethyl-1,3-dioxolane in 1,000 ml of hexamethylphosphoric acid triamide, with stirring; by means of cooling, the temperature is kept at 0-10 during the addition. The reaction mixture is then stirred for a further 5 hours with ice-cooling and then for 15 hours at room temperature. The reaction mixture is poured onto ice and extracted with diethyl ether. The organic extract is washed with a concentrated aqueous solution of sodium chloride, dried and evaporated. The residue is dissolved in 1,000 ml of ethanol, 100 ml of 2 N hydrochloric acid are added and the mixture is left to stand for 8 hours. After evaporating off the solvent, the residue is rendered alkaline with a concentrated solution of sodium hydroxide in water and extracted with ethyl acetate. Evaporating off the solvent yields a crude product from which crystalline 3-(3-methoxy-2-pyridyloxy)-1,2-propanediol with a melting point of 62-65 is obtained on the addition of diethyl ether.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 20265-37-6, 3-Methoxy-2-nitropyridine.
Reference:
Patent; Ciba-Geigy Corporation; US4264599; (1981); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem