The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 956010-87-0, name is 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 956010-87-0
To compound 12 (150 mg, 0.80 mmol) and N-methyl-N-phenylhydrazinecarbothioamide (174 mg, 0.96 mmol) was added a 1N aqueous sodium hydroxide solution (3.0 mL), and the mixture was heated in a microwave oven to 150 C for 10 min. The mixture was diluted with water and extracted twice with ethyl acetate. The solvent was evaporated, and the residue was purified by preparative HPLC to yield 159 mg (64 %) of the title compound as a tan solid. 1H NMR (400 MHz, DMSO-d6): delta 3.60 (s, 3H), 7.35-7.40 (m, 2H), 7.52 (t, J=7.7Hz, 2H), 7.56-7.59 (m, 2H), 8.60 (dd, J=7.3, 1.5Hz, 1H), 8.64 (dd, J=4.4, 1.5Hz, 1H), 14.13 (s, 1H). 13C NMR (125 MHz, DMSO-d6): delta 40.61, 111.6, 118.5, 124.5, 127.0, 130.0, 130.8, 136.0, 146.5, 150.1, 151.7, 152.5, 169.3. HRMS m/z calcd for C15H12N6S + [H+]: 309.0917; found: 309.0908.
With the rapid development of chemical substances, we look forward to future research findings about 956010-87-0.
Reference:
Article; Schirok, Hartmut; Griebenow, Nils; Fuerstner, Chantal; Dilmac, Alicia M.; Tetrahedron; vol. 71; 34; (2015); p. 5597 – 5601;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem