Adding some certain compound to certain chemical reactions, such as: 393-53-3, name is 3-Fluoroisonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 393-53-3. 393-53-3
General Procedure: To a 50 mL round bottom flask equipped with a stir bar and a reflux condenser were added 3-fluoroisonicotinic acid (1.0 g, 7.09 mmol), methanol (10 mL) and sulfuric acid (4.2 mL). The reaction mixture was heated at 70 C overnight, cooled to room temperature and concentrated in vacuo. The residue was cooled in an ice bath, basified to pH 9 using saturated aqueous sodium carbonate and extracted with ethyl acetate (2x). The combined organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give the desired product as yellow oil (1.03 g, 94 %). 1H NMR (300 MHz, CDCl3): delta 8.62 (d, IH), 8.54 (d, IH), 7.77 (t, IH), 3.98 (s, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 393-53-3.
Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/87135; (2007); A2;,
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