Related Products of 13534-98-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13534-98-0, name is 4-Amino-3-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows.
Ethyl (3-bromopyridin-4-yl)carbamate (S7).3-Bromopyridin-4-amine (100 mol%) was dissolved in CH2Cl2 (0.2 M), and cooled to 0 C. Ethyl chloroformate (110 mol%) was added at 0 C, then diisopropylethylamine (150 mol%) was added. The mixture was stirred at 0 C for 30 min, warmed to ambient temperature, and stirredor additional 2-3 h. After completion, the mixture was diluted with CH2Cl2, and washed withwater and brine. The combined aqueous layer was washed with CH2Cl2. The combined organiclayer was dried over anhydrous Na2SO4, and concentrated in vacuo. The title compound S7 was obtained as an off white solid in 86% yield (610.6 mg, 2.49 mmol) after flash column chromatography (hexanes/EtOAc = 1:1). 1H NMR (asterisk denotes minor rotamer peaks, 400 MHz, CDCl3) delta 8.82* (d, J = 0.5 Hz, 1H), 8.59* (d, J = 5.6 Hz, 1H), 8.59 (d, J = 0.4 Hz, 1H), 8.40 (dd, J = 5.6, 0.6 Hz, 1H), 8.15 (d, J =5.6 Hz, 1H), 7.30 (br s, 1H), 7.22* (dd, J = 5.1, 0.5 Hz, 1H), 4.28 (q, J = 7.1 Hz, 2H), 4.24* (q, J= 7.1 Hz, 2H), 1.35 (t, J = 7.1 Hz, 3H), 1.23* (t, J = 7.1 Hz, 3H). 13C NMR (asterisk denotes minor rotamer peaks, 100 MHz, CDCl3) delta 153.0*, 152.4*, 151.6,149.5, 142.8, 124.7*, 113.2, 109.7, 63.8*, 62.2, 14.4, 14.0*. IR (neat) 3405, 2980, 1739, 1582, 1506, 1236, 1205 cm-1.HRMS (ESI+) calcd. for C8H10BrN2O2 [M+H]+ 244.9920, found 244.9920.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13534-98-0, 4-Amino-3-bromopyridine.
Reference:
Article; Shin, Inji; Ramgren, Stephen D.; Krische, Michael J.; Tetrahedron; vol. 71; 35; (2015); p. 5776 – 5780;,
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