Electric Literature of 128071-98-7 ,Some common heterocyclic compound, 128071-98-7, molecular formula is C5H3BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of 4-bromo-2-fluoropyridine (528 mg, 3 mmol), phenylboronic acid (399 mg, 3.3 mmol), Pd(PPFi3)4(69 mg, 0.06 mmol) in toluene/ethanol (4:1, 25 ml) was added a solution of Na2C03 (1.27 g, 12 mmol) in water (10 ml). The resulting yellow solution was stirred at 80 C for 2 hours, during which time the solution turned black. After cooling to ambient temperature the reaction mixture was extracted with EtOAc (3 x 50 ml). The combined organic layers were the washed with brine (50 ml), dried over MgS04, filtered and concentrated in vacuo. The crude product was purified by hot filtration from MeOH followed by silica gel chromatography (5% EtOAc in n-pentane) to the title compound as a light yellow solid (490 mg, 2.8 mmol, 94%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 128071-98-7, 4-Bromo-2-fluoropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ANDREN, Per; ODELL, Luke; NILSSON, Anna; SHARIATGORJI, Mohammadreza; SAeVMARKER, Jonas; (0 pag.)WO2019/172830; (2019); A1;,
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