The origin of a common compound about 4-Chloro-2-methoxynicotinaldehyde

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1008451-58-8, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 1008451-58-8, 4-Chloro-2-methoxynicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1008451-58-8, blongs to pyridine-derivatives compound. SDS of cas: 1008451-58-8

A mixture of 4-chloro-3-formyl-2-methoxypyridine (0.43 g, 2.51 mmol), 4- Boc-aminopiperidine (0.7 g, 3.5 mmol), and DIEA (1.0 mL, 2.5 eq.) in ACN (14 mL) was stirred at 100 C for 40 min. After removal of the volatile solvent, the residue was purified by column chromatography to afford the title compound (0.84 g, 100%). MS (M+H)+: 336.5.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1008451-58-8, its application will become more common.

Reference:
Patent; CRINETICS PHARMACEUTICALS, INC.; HAN, Sangdon; KIM, Sun Hee; ZHU, Yunfei; (149 pag.)WO2018/170284; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem