Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 670253-37-9, name is 4-Chloro-5-iodopyridin-2-amine. A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Chloro-5-iodopyridin-2-amine
In a one-neck round bottom flask, 90.7 g (357.1 mmol) of compound IF was added to 500 ml of NMP, and 21.4 g (182.1 mmol) of Zn(CN)2 was added, and 41 g (35.7 mmol) of Pd(PPh3)4 was quickly added, reacted at 135C for 5 h. After the reaction was completed, a brown oily liquid was given. The reaction mixture was slowly poured into 3 L of ice water under stirring, and a large amount of tan solid was precipitated, filtered, washed with water and dried to give compound 1G, ESI-MS m/z: 154.2 [M+H]+.
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Reference:
Patent; Shanghai Zheye Biotechnology Limited-Liability Company; LIU, Jianyu; ZHANG, Haidong; (30 pag.)EP3564242; (2019); A1;,
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