Adding a certain compound to certain chemical reactions, such as: 60781-83-1, 4-Phenylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
Add tri-tert-butylphosphine (4.4 mL of a 1.0 M solution in toluene, 1.48 g, 0.05 mmol), palladium acetate (0.4 g, 1.83 mmol) and sodium t-butoxide (52.7 g, 549 mmol) to 1-3 (30.83) A solution of g, 80.44 mmol) and 1-4 (13.69 g, 80.44 mmol) in degassed toluene (500 mL), and the mixture was heated under reflux for 2 hours.The reaction mixture was cooled to room temperature, diluted with toluene and filtered over EtOAc.The filtrate was diluted with water and extracted with toluene and the organic phases were combined and evaporated in vacuo. The residue was filtered through silica gel (heptane / dichloromethane) and crystallised from isopropyl alcohol.Intermediate 1-5 38.43 g was obtained in a yield of 81.32%.
The synthetic route of 60781-83-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhang Hong; Cai Hui; (28 pag.)CN108440524; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem