Synthetic Route of 4021-08-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4021-08-3, name is 4-Methylpicolinic acid. A new synthetic method of this compound is introduced below.
Step 3. The preparation of 4-methyl-pyridine-2-carboxylic acid methyl ester: 4-Methyl-pyridine-2-carboxylic acid (4.39 g, 25.3 mmol) was suspended in THF. A solution of diazomethane (60 mL, 0.43 M) in THF was added dropwise and the reaction was stirred for three hours. Several drops of AcOH were added to quench the reaction, then saturated bicarbonate solution was added. The reaction was diluted with EtOAc and the layers were separated. The aqueous layer was washed twice with EtOAc and the organic layers were combined, dried over Na2SO4, and concentrated. The residue was chromatographed on silica gel eluding with 4% MeOH/CH2Cl2 to give 1.17 g (31%) of the desired product as an oil. MS: 152 (M+1 for C8H9N1O2); 1H-NMR (CDCl3)delta2.40 (s, 3 H), 3.97 (s, 3 H), 7.26 (d, 1 H, J=4.2 Hz), 7.94 (s, 1 H), 8.56 (d, 1 H, J=4.9 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,4021-08-3, 4-Methylpicolinic acid, and friends who are interested can also refer to it.
Reference:
Patent; Warner-Lambert; US6251919; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem