Application of 490-11-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.490-11-9, name is Pyridine-3,4-dicarboxylicacid, molecular formula is C7H5NO4, molecular weight is 167.12, as common compound, the synthetic route is as follows.
Pyridine-3,4-dicarboxylic acid (40g, 0.24mmol) was added to SOCl2 (400mL) and heated to reflux for 80 deg C fo 3h. the solvent was distilled off under reduced pressure, at 0 added dropwise to methanol (200 mL), and stirred for half an hour at room temperature, the solvent was distilled off under reduced pressure, the solid was dissolved with ethyl acetate (a 500 mL), washed twice with saturated NaHCO3 solution, the organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated to give the title compound (41g, yield 87.8 %)
Statistics shows that 490-11-9 is playing an increasingly important role. we look forward to future research findings about Pyridine-3,4-dicarboxylicacid.
Reference:
Patent; Shandong Xuan Bamboo Pharmaceutical Technology Co., Ltd.; Wu, Yong qian; (49 pag.)CN105461714; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem