Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 571189-49-6, name is 5-(4-Methylpiperazin-1-yl)pyridin-2-amine. A new synthetic method of this compound is introduced below., category: pyridine-derivatives
4-(2-Dimethylcarbonyl-2-carbonyl-ethylamino)-2-pyrimidinecarboxylic acid (1.26 g, 1.2 eq),5-(4-Methyl-piperazin-1-yl)-piperidin-2-amino (0.8 g, 1 eq)And triethylamine (500 muL) in DMF (15 mL),Then add HBTU(1.51 g, 1.5 eq). The mixture was stirred at room temperature for 16 hours.Then EtOAc (50 mL) and saturated NaHCO3 solution(15 mL), the layers were separated and EtOAc EtOAcThe combined organic layers were dried (MgSO4).Filtration and evaporation to dryness, the residue was purified by column chromatography.0.98 g of the target compound 5 was obtained as a white solid(yield: 46%),Its nuclear magnetic resonance spectrum data is as follows:
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Reference:
Patent; Jiangxi Runze Pharmaceutical Co., Ltd.; Liao Niansheng; Hu Xiande; Zhou Liming; Sui Guilan; (22 pag.)CN109568256; (2019); A;,
Pyridine – Wikipedia,
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