Electric Literature of 858116-66-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.858116-66-2, name is 5-Bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine, molecular formula is C16H25BrN2Si, molecular weight is 353.3726, as common compound, the synthetic route is as follows.
To a 50 ml reaction flask at room temperature, the compound of formula II (4.08 g, 11.5 mmol) was added, Copper acetylacetonate (0.15g, 0.575mmol), BetaEtaMuRhoO (0.15g, 0 · 575mmol), lithium hydroxide monohydrate (2 · 42g, 57.5mmol), 18ml of DMSO, 4.5ml of water, stirring was turned on, replaced with nitrogen, and the temperature was raised to an internal temperature of 100 C. Temperature reaction for 6 hours. Control raw material reaction is over, stop heating, cool to room temperature (20-30 C), add water 100ml, adjust PH to 6 with 2N dilute hydrochloric acid, precipitation of solids, suction filtration, aqueous phase with ethyl acetate 50ml * 3 Extraction, combining the organic phases, washing once with water and saturated aqueous sodium chloride solution, drying over anhydrous sodium sulfate, and concentrating the solvent to obtain the compound of formula III. Yield: 1.2 g, yield: 78.5%.
The chemical industry reduces the impact on the environment during synthesis 858116-66-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shanghai Hongbozhiyuan Pharmaceutical Co., Ltd.; Zhuang Yinqiang; Peng Shaoping; Jiang Hui; (11 pag.)CN107434807; (2017); A;,
Pyridine – Wikipedia,
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