Electric Literature of 183208-35-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 183208-35-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under argon atmosphere, 1.86 g (9.4 mmol) of 5-bromo-7-azaindole was dissolved in 225 mL of dry acetonitrile and 45 mL of cc. acetic acid. The solution was heated to 40 C, 5 g of Selectfluor (l -Chloroniethyl-4-fluoro-l,4-diazoniabicyclo[2.2.2]octane bis(tetrafiuoroborate)) was added, and the resulting mixture was heated to 80 C’C, and stirred overnight. It was evaporated to dryness, and the crude product was dissolved in 200 mL of EtOAc, and washed twice with water. The organic layer was dried over NaiiSOr and was evaporated. After flash column chro atography (CHzCh/MeOH ::: 99/1) 362 mg of 5-bromo- 3-fluoro-7-azaindole was isolated.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 183208-35-7, 5-Bromo-1H-pyrrolo[2,3-b]pyridine.
Reference:
Patent; RICHTER GEDEON NYRT.; LEDNECZKI, Istvan; ELES, Janos; TAPOLCSANYI, Pal; HORVATH, Anita; NEMETHY, Zsolt; LEVAY, Gyoergy Istvan; GALAMBOS, Janos; (0 pag.)WO2020/12424; (2020); A1;,
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