Electric Literature of 1215387-58-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1215387-58-8, name is 5-Bromo-1H-pyrrolo[2,3-c]pyridine, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A stirred solution of 5-bromo-lH-pyrrolo[2,3-c]pyridine (2.22 g, 11.3 mmol) in DMF (30 ml) at ambient temperature was treated with potassium hydroxide (2.53 g, 45.1 mmol). After 10 minutes, iodine (3.15 g, 12.4 mmol) was added and the resulting mixture was stirred for 2 hours. The mixture was diluted with water and extracted with EtOAc. The organic phase was washed with brine, dried over Na2S04 and concentrated in vacuo. The residue was triturated with water, filtered and dried in vacuo to afford the desired product as an orange solid (3.39 g, 93%). LCMS (Method C): Rt= 3.14 min, m/z [M+H]+ = 323/325.
According to the analysis of related databases, 1215387-58-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; HYND, George; TISSELLI, Patrizia; MACLEOD, Calum; MANN, Samuel, Edward; MONTANA, John, Gary; PRICE, Stephen, Colin; (91 pag.)WO2016/62789; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem