Related Products of 823221-93-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.823221-93-8, name is 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine, molecular formula is C6H2BrClF3N, molecular weight is 260.44, as common compound, the synthetic route is as follows.
A mixture of 5-bromo-2-chloro-4-(trifluoromethyl)pyridine (6.0 g, 23 mmol), tributyl(1-ethoxyvinyl)stannane (8.3 g, 23 mmol), and Pd(PPh3)4 (1.3 g, 1.2 mmol) in toluene (50 mL) was sparged with nitrogen for 5 min and then stirred at 120 C. for 1 h. After this time, the mixture was allowed to cool to rt and then poured into saturated aqueous KF solution (100 mL). The resulting mixture was stirred vigorously for 30 min and then extracted twice with EtOAc. The organic extracts were combined, dried with anhydrous Na2SO4, filtered, and then concentrated. The residue was purified by silica gel chromatography (0?5% EtOAc/petroleum ether) to afford the title compound as a yellow oil.
Statistics shows that 823221-93-8 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine.
Reference:
Patent; Janssen Pharmaceutica NV; Goldberg, Steven; Martin, Connor L.; Fennema, Elizabeth G.; Kummer, David A.; Nishimura, Rachel T.; Fourie, Anne M.; Xue, Xiaohua; (94 pag.)US2019/382373; (2019); A1;,
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