Synthetic Route of 164513-39-7 ,Some common heterocyclic compound, 164513-39-7, molecular formula is C7H8BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: General procedure for the synthesis of example compounds in a library setupMethod AStep 1 : To a solution of the required building block (1 eq.) in toluene (10 mL) in a sealed tube, K2C03 (3 eq.), the corresponding bromo compound (1.2 eq) and /V./V-dimethylethylene diamine (0.5eq) were added. The RM was degassed by purging Ar for 30 min. Then, Cul (0.5 eq.) was added and Argon was purged for further 30 min. The tube was sealed with a Teflon screw cap and the RM was stirred at 100C for 2 to 6 d. The RM was cooled to rt and diluted with toluene (20 mL) and filtered over a plug of celite. The combined filtrate was concentrated under reduced pressure. The residue was purified by CC (silica gel) to afford the respective products.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,164513-39-7, its application will become more common.
Reference:
Patent; GRUeNENTHAL GMBH; VOSS, Felix; RITTER, Stefanie; NORDHOFF, Sonja; WACHTEN, Sebastian; OBERBOeRSCH, Stefan; KLESS, Achim; WO2015/22073; (2015); A1;,
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