The origin of a common compound about 5-Bromo-3-chloropicolinaldehyde

At the same time, in my other blogs, there are other synthetic methods of this type of compound,885168-04-7, 5-Bromo-3-chloropicolinaldehyde, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.885168-04-7, name is 5-Bromo-3-chloropicolinaldehyde, molecular formula is C6H3BrClNO, molecular weight is 220.4511, as common compound, the synthetic route is as follows.Computed Properties of C6H3BrClNO

Methane sulfonic acid (35.7 ml, 550.45 mmol, 10 eq) was added to a solution of 5-bromo-3-chloro-picolinaldehyde (see Example 88) (12 g, 55.04 mmol, I eq) in DCM (200 ml) at 0C. But-3-en-1-ol (4.5 ml, 55.04 mmol, 1 eq) was added and the mixture stirred for 16 h at RT. The RM was quenched with sat. Na2CO3 solution and extracted with DCM (3 X 150 ml). The organics were washed with water (150 ml) and brine (150 ml), dried (Na2SQ4) and the the solvent was distilled-off under reduced pressure to afford the desired product (18 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,885168-04-7, 5-Bromo-3-chloropicolinaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
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