Synthetic Route of 113118-81-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 113118-81-3, name is 5-Bromonicotinaldehyde. A new synthetic method of this compound is introduced below.
INTERMEDIATE 75 PREPARATION OF 5-FORMYLPYRIDINE-3-CARBONITRILE A mixture of of 5-bromopyridine-3-carbaldehyde (10 g, 53.8 mmol) and cuprous cyanide (7.20 g, 80.6 mmol) in N,N-dimethylformamide (40 mL) was heated to 140 FontWeight=”Bold” FontSize=”10″ C and stirred under a nitrogen atmosphere overnight. After being cooled to room temperature, the reaction mixture was diluted with water (80 mL) and filtered. The filtrate was extracted with EtOAc (3 x 50 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (EtOAc-petroleum ether, 1:4) to afford the title compound (1.86 g, 26%) as a yellow solid.1H NMR (400 MHz, CDCl3) delta 10.17 (s, 1H), 9.30 (s, 1H), 9.14 (s, 1H), 8.45 (t, J = 2.0 Hz, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,113118-81-3, 5-Bromonicotinaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; DENALI THERAPEUTICS INC.; BONANOMI, Giorgio; ESTRADA, Anthony A.; FENG, Jianwen A.; FOX, Brian; LESLIE, Colin Philip; LYSSIKATOS, Joseph P.; NAPOLITANO, Carmela; POZZAN, Alfonso; SUDHAKAR, Anantha; SWEENEY, Zachary K.; TONELLI, Federica; DE VICENTE FIDALGO, Javier; (232 pag.)WO2017/96301; (2017); A1;,
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