Related Products of 874959-68-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride. A new synthetic method of this compound is introduced below.
Ethyl 5-amino-3-methylbenzofuran-2-carboxylate (0.23 g, 1.05 mmol), 5-bromopyridine-2-sulfonyl chloride (0.54 g, 2.10 mmol), potassium carbonate(0.29 g, 2.10 mmol) was added successively to 30 mL of dichloromethane, and the mixture was stirred overnight at room temperature, and potassium carbonate was filtered off, and the residue was purified by column chromatography to yield 0.43 g (yield: 93.3%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,874959-68-9, 5-Bromopyridine-2-sulfonyl chloride, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; You Qidong; Wei Jinlian; Jiang Zhengyu; Guo Xiaoke; Xu Xiaoli; Zhang Xiaojin; (44 pag.)CN107619384; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem