Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1357945-27-7, name is 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine. A new synthetic method of this compound is introduced below., Product Details of 1357945-27-7
A mixture 5-chloro-3-iodo-lH-pyrazolo[4,3-b]pyridine (XIV) (23.5 g, 84.1 mmol) and p-toluenesulfonic acid (3.20 g, 16.82 mmol) in THF (200 mL) was heated to 60C for 12 h. The solvents were concentrated and the residue taken in EtOAc (300 mL), washed with sat. NaHCC (200 mL), and brine solution (200 mL). The organic layer was dried over anhydrous Na2SC>4, and concentrated to give crude 5-chloro-3-iodo-l-(tetrahydro-2H-pyran-2-yl)-lH- pyrazolo[4,3-b]pyridine (XV) as yellow gummy syrup (30.2 g, 83.1 mmol, 98.8% yield), which was used without further purification for the Suzuki coupling. ESIMS found for C11H11CIIN3O mlz 364.0 (M+H).
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Reference:
Patent; SAMUMED, LLC.; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; MARAKOVITS, Joseph Timothy; BOLLU, Venkataiah; HOOD, John; (299 pag.)WO2017/24015; (2017); A1;,
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