Electric Literature of 886365-46-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.886365-46-4, name is 5-Chloro-3-methylpyridine-2-carboxylic acid, molecular formula is C7H6ClNO2, molecular weight is 171.58, as common compound, the synthetic route is as follows.
Thionyl chloride (71 mul, 962 mumol) is added to a mixture of 5-chloro-3-methyl-pyridine-2-carboxylic acid (150 mg, 874 mumol), toluene (1 ml) and DMF (20 mul). The mixture is heated to 60 C. for 1 hour. The mixture is concentrated in vacuo and the crude product used directly without further purification.
The chemical industry reduces the impact on the environment during synthesis 886365-46-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; REISER, Ulrich; US2015/57286; (2015); A1;,
Pyridine – Wikipedia,
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