Related Products of 79456-33-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.79456-33-0, name is 5-Chloro-3-(trifluoromethyl)pyridin-2-amine, molecular formula is C6H4ClF3N2, molecular weight is 196.56, as common compound, the synthetic route is as follows.
To a stirred solution of 5-chloro-3-(trifluoromethyl)pyridin-2-amine (Intermediate 47; CAS79456-33-0, 10 g, 50.9 mmol) in aqueous HBr (48 %, 56.7 g, 336 mmol) at -10 C wasadded bromine (23.6 g, 147.5 mmol) dropwise over 20 minutes, followed by a solution ofsodium nitrite (10.2 g, 147.8 mmol) in water (18 mL). The reaction was stirred at ambienttemperature for 2 hours and was basified (pH 9-10) and extracted into diethyl ether. Theorganic was washed with brine, dried (Na2504), filtered and concentrated in vacuo toafford the title compound without further purification.MS ES: 262
The chemical industry reduces the impact on the environment during synthesis 79456-33-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; GOLDBY, Anne; JENKINS, Kerry; TEALL, Martin; WO2015/79224; (2015); A1;,
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