Adding a certain compound to certain chemical reactions, such as: 107504-08-5, 5-Fluoro-2-picolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H4FNO2, blongs to pyridine-derivatives compound. COA of Formula: C6H4FNO2
To a solution of 5-fluoropicolinic acid (500 mg, 3.54 mmol) in DCM (14 mL)/DMF (3.5 mL) was added l-hydroxy-7 azabenzotriazole (HOAt) (487 mg, 3.58 mmol), and EDC (713 mg, 3.72 mmol). The resulting mixture was stirred at 23 0 for 10 min followed by the addition of ammonium hydroxide (641 mu, 4.61 mmol). The reaction mixture was stirred at 23 C for 16 hours. Saturated aqueous NaHC03 solution was added to the reaction and the resulting mixture was extracted with DCM (3 x 40 mL). Combined organic phases were washed with water, brine, dried (MgSC^), filtered, and concentrated to give 275 mg of the crude desired product as pale yellow oil, which was used without further purification: MS(ES,m/z): 141.1 (M + 1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,107504-08-5, 5-Fluoro-2-picolinic acid, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn; FU, Jianmin; XU, Shimin; PAONE, Daniel; LI, Jing; GINNETTI, Anthony; Lim, John; WO2015/51479; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem