Electric Literature of 22187-96-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22187-96-8, name is 5-Methoxypicolinaldehyde, molecular formula is C7H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of 5-methoxypicolinaldehyde (326mgs, 2.36mmol) in MeOH (10 mL) was added NaBH4 (71.9 mg, 1.90 mmol) at O0C. The mixture was stirred at O0C for 10 min after concentration in vacuo, the residue was purified with ISCO MPLC (40-80% EtOAc/hexane) to yield the title compound as a colorless oil (298 mg, 90 %). 1H NMR (CDCl3) 68.28 (d, 1 H), 7.09 – 7.27 (m, 2 H), 4.73 (s, 2 H), 3.89 (s, 3 H). MS (M+H+) = 140.
According to the analysis of related databases, 22187-96-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/27746; (2009); A1;,
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