Synthetic Route of 56026-36-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate, molecular formula is C8H9NO3, molecular weight is 167.16, as common compound, the synthetic route is as follows.
Dess-Martin periodinane (3.0 g, 7.2 mmol) was added slowly to the mixture of compound 38 (1.0 g,6.0 mmol) in DCM (10 mL). The resulting mixture continued to stir at room temperature overnight.The reaction was quenched with water. The aqueous phase was extracted with EtOAc. The combinedorganic phases were then processed in the usual way and chromatographed (3:1 petroleum ether/EtOAc)to yield compound 39 (0.85 g, 86%).
The chemical industry reduces the impact on the environment during synthesis 56026-36-9, I believe this compound will play a more active role in future production and life.
Reference:
Article; Wang, Wen-Long; Yang, Dong-Lin; Gao, Li-Xin; Tang, Chun-Lan; Ma, Wei-Ping; Ye, Hui-Hua; Zhang, Si-Qi; Zhao, Ya-Nan; Xu, Hao-Jie; Hu, Zhao; Chen, Xia; Fan, Wen-Hua; Chen, Hai-Jun; Li, Jing-Ya; Nan, Fa-Jun; Li, Jia; Feng, Bainian; Molecules; vol. 19; 1; (2014); p. 102 – 121;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem