Reference of 588729-99-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 588729-99-1, name is 3-Amino-5-bromo-2-chloropyridine, molecular formula is C5H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In vessel 1, thionyl chloride (110.0 kg) was added into water (430 kg) at Ca. 0C. The mixture was stirred at Ca. 3 C for 7 h before copper(I) chloride (0.27 kg) was added at Ca. 3 C.In vessel 2, 5-bromo-2-chloropyridin-3-amine (28.2 kg, 136 Mol) was mixed with 35% aqueous hydrochloric acid solution (202 kg) at Ca. 5C. A solution of sodium nitrite (8.5-14.1 kg) in water (19.7-25.4 kg) was then added at Ca. -10 C.The solution in Vessel 2 was added to the solution in vessel 1 while maintaining the temperature at Ca. -7C. The reaction mixture was stirred for 2 h at Ca. -2C. The solid product wasisolated by filtration and dried in vacuo at Ca. 23 C for 18 h. 30.9 kg of the title Compound was obtained in 66 %th yield and 84.3 % assay.
According to the analysis of related databases, 588729-99-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ANDERSON, Niall Andrew; BARTON, Nicholas Paul; CAMPOS, Sebastien Andre; CANNONS, Edward Paul; COOPER, Anthony William James; DOWN, Kenneth David; DOYLE, Kevin James; HAMBLIN, Julie Nicole; HENLEY, Zoe Alicia; INGLIS, Graham George Adam; LE GALL, Armelle; PATEL, Vipulkumar Kantibhai; PEACE, Simon; SHARPE, Andrew; WHITE, Gemma Victoria; (129 pag.)WO2019/20657; (2019); A1;,
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