The origin of a common compound about 6-Chloro-2-methyl-3-nitropyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,22280-60-0, 6-Chloro-2-methyl-3-nitropyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22280-60-0, name is 6-Chloro-2-methyl-3-nitropyridine, molecular formula is C6H5ClN2O2, molecular weight is 172.57, as common compound, the synthetic route is as follows.HPLC of Formula: C6H5ClN2O2

General procedure: To a solution of MeONa(obtained by dissolving 0.388 g (0.017 mol) of sodium metal in 15 mL of absolute MeOH) 0.016 mol2-chloropyridine 2a-d was added. The mixture was boiled for 4 h, the precipitated NaCl was filteredo, the filtrate was evaporated and the residue was chromatographed on a column (SiO2, chloroform).The yields, m.p. of products 3a-d and literature references are given in Table 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,22280-60-0, 6-Chloro-2-methyl-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Article; Babaev, Eugene V.; Rybakov, Victor B.; Molecules; vol. 25; 7; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem