Adding a certain compound to certain chemical reactions, such as: 1211532-15-8, 6-Methoxy-5-(trifluoromethyl)nicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Methoxy-5-(trifluoromethyl)nicotinic acid, blongs to pyridine-derivatives compound. Recommanded Product: 6-Methoxy-5-(trifluoromethyl)nicotinic acid
(4-bromophenyl) ((2S) -2- (4-chlorophenyl) piperazin-1-yl) methanone hydrochloride (2 g)6-methoxy-5- (trifluoromethyl) nicotinic acid (1.2 g),HATU (3 g),Triethylamine (2 ml)And DMF (15 ml) was stirred at room temperature for 1 hour. The mixture was extracted with ethyl acetate and water. The obtained organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (NH, hexane / ethyl acetate) to give the title compound (2.9 g).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1211532-15-8, 6-Methoxy-5-(trifluoromethyl)nicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MIZOJIRI, RYO; CARY, DOUGLAS ROBERT; HIRAYAMA, TAKAHARU; ITO, MASAHIRO; TANAKA, TOSHIO; IMAEDA, YASUHIRO; SASAKI, SHIGEKAZU; TAKAMI, KAZUAKI; FUKUDA, KOICHIRO; KAMAURA, MASAHIRO; MORISHITA, NAO; (133 pag.)JP2017/222626; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem