In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. Quality Control of 6-Methyl-1H-pyrrolo[2,3-b]pyridine
Azaindole 98 (55 mg, 0.42 mmol) was dissolved in 2 ml anhydrous dimethylformamide under nitrogen. Sodium hydride (60% dispersion in oil, 22 mg, 0.54 mmol) was added and the mixture was stirred for 45 min at room temperature. Bromide 10c (180 mg, 0.50 mmol) dissolved in 2 ml anhydrous dimethylformamide was added and the mixture was stirred for 3 h. The mixture was poured over ice-water and was extracted three times with ether. The combined organics were dried over anhydrous magnesium sulphate, filtered and evaporated under reduced pressure to give crude 109 (170 mg) as a yellow oil. Used as such without further purification. Purity 90%. NMR spectrum not recorded. UPLC/MS (3 min) retention time 1.97 min. LRMS: m/z 411 (M+1).
The synthetic route of 824-51-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Buil, Maria Antonia; Calbet, Marta; Castillo, Marcos; Castro, Jordi; Esteve, Cristina; Ferrer, Manel; Forns, Pilar; Gonzalez, Jacob; Lopez, Sara; Roberts, Richard S.; Sevilla, Sara; Vidal, Bernat; Vidal, Laura; Vilaseca, Pere; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 102 – 133;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem