Application of 56622-54-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56622-54-9, name is (6-Methylpyridin-3-yl)methanamine, molecular formula is C7H10N2, molecular weight is 122.17, as common compound, the synthetic route is as follows.
[0557] To a solution of compound VII (0.5 g, 1.39 mmol, 1 eq) in DMF (50 mL) were added HATU (0.7 g, 1.8 mmol, 1.3 eq) and DIPEA (0.74 mL, 4.17 mmol, 3 eq) under argon atmosphere at 0 C. A DMF solution of C-(6-methyl-pyridin-3-yl)-methylamine (0.25 g, 2.09 mmol, 1.5 eq) was added and the resulting mixture was stirred at 23 C for 16 h. The mixture was diluted with ice water (40 mL) and the organic components were extracted with EtOAc (2 x 50 mL) and 10% MeOH/CH2C12 (50 mL), and the combined extracts were washed with brine (50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to provide the crude compound. The crude product was purified by flash Combiflash chromatography using 100-200 mesh silica gel eluting with 5% MeOH/CH2C12 to obtain compound (0.4 g, 62%) as an orange solid. 1H NMR (400 MHz, DMSO-d6) oe 9.53 (t, 1H, J = 6 Hz), 9.18 (s, 1H), 8.47 (s, 1H), 8.37 (s, 1H), 7.94 (s, 1H),7.70-7.44 (m, 2H), 7.23 (d, 1H, J = 8 Hz), 4.53 (d, 2H, J = 5 Hz), 2.45 (s, 3H). LCMS: m/z =463.0 [M+j, 465.0 [M+21, RT = 1.94 minutes; (Program Ri, Column W).
Statistics shows that 56622-54-9 is playing an increasingly important role. we look forward to future research findings about (6-Methylpyridin-3-yl)methanamine.
Reference:
Patent; ASANA BIOSCIENCES, LLC; THOMPSON, Scott; VENKATESAN, Aranapakam; PRIESTLEY, Tony; KUNDU, Mrinal; SAHA, Ashis; WO2015/95128; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem