HPLC of Formula: 625-82-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Highly efficient near-infrared BODIPY phototherapeutic nanoparticles for cancer treatment. Author is Zhang, Yuandong; Yang, Zhiyu; Zheng, Xiaohua; Chen, Li; Xie, Zhigang.
BODIPYs are highly potential photoactive agents for cancer theragnostics. The rational design of BODIPY-based photoactive nanodrugs with high efficiency and near-IR (NIR) absorption is imperative. Herein, we developed a donor-acceptor-donor (D-A-D) organic photosensitizer (PS) (BODIPY, named NBB), which possessed strong absorption in the NIR region due to the multi-intersection of intramol. charge transfer (ICT), photoinduced electron transfer (PET), and heavy atom effects. Through a nanopptn. method, NBB nanoparticles (NPs) were facilely prepared The as-prepared NBB NPs exhibited favorable water-stability and photostability. In particular, the outstanding photon absorption capacity endows the NPs with high photothermal conversion efficiency (η = 53.8%) and active singlet oxygen (1O2) generation ability upon 808 nm laser irradiation, and promotes their tumor inhibition efficiency via the combination of photothermal/photodynamic therapy (half-maximal inhibitory concentration IC50 = 8.11 and 7.77 μM for HeLa and HepG2 cells, resp.). Together with the favorable synthetic yield and excellent antitumor effect, we envision that this exploration can provide beneficial guidance for the clin. translation of BODIPY-based PSs for phototherapy.
《Highly efficient near-infrared BODIPY phototherapeutic nanoparticles for cancer treatment》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4-Dimethyl-1H-pyrrole)HPLC of Formula: 625-82-1.